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Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production
Fatty acid synthase (FASN) is a key enzyme in the synthesis of palmitate, the precursor of major nutritional, energetic, and signaling lipids. FASN expression is upregulated in many human cancers and appears to be important for cancer cell survival. Overexpression of FASN has also been found to asso...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3617951/ https://ncbi.nlm.nih.gov/pubmed/23319743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M033811 |
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