Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production

Fatty acid synthase (FASN) is a key enzyme in the synthesis of palmitate, the precursor of major nutritional, energetic, and signaling lipids. FASN expression is upregulated in many human cancers and appears to be important for cancer cell survival. Overexpression of FASN has also been found to asso...

Full description

Saved in:
Bibliographic Details
Main Authors: Liu, Hailan, Wu, Xi, Dong, Zizheng, Luo, Zhiyong, Zhao, Zhenwen, Xu, Yan, Zhang, Jian-Ting
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2013
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617951/
https://ncbi.nlm.nih.gov/pubmed/23319743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M033811
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items