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Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production

Fatty acid synthase (FASN) is a key enzyme in the synthesis of palmitate, the precursor of major nutritional, energetic, and signaling lipids. FASN expression is upregulated in many human cancers and appears to be important for cancer cell survival. Overexpression of FASN has also been found to asso...

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Bibliographic Details
Main Authors: Liu, Hailan, Wu, Xi, Dong, Zizheng, Luo, Zhiyong, Zhao, Zhenwen, Xu, Yan, Zhang, Jian-Ting
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617951/
https://ncbi.nlm.nih.gov/pubmed/23319743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M033811
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