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Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration

Leukotriene (LT)A(4) and closely related allylic epoxides are pivotal intermediates in lipoxygenase (LOX) pathways to bioactive lipid mediators that include the leukotrienes, lipoxins, eoxins, resolvins, and protectins. Although the structure and stereochemistry of the 5-LOX product LTA(4) is establ...

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Библиографические подробности
Главные авторы: Jin, Jing, Zheng, Yuxiang, Boeglin, William E., Brash, Alan R.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617949/
https://ncbi.nlm.nih.gov/pubmed/23242647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M033746
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