Formation of a Cyclopropyl Epoxide via a Leukotriene A Synthase-related Pathway in an Anaerobic Reaction of Soybean Lipoxygenase-1 with 15S-Hydroperoxyeicosatetraenoic Acid: EVIDENCE THAT OXYGEN ACCESS IS A DETERMINANT OF SECONDARY REACTIONS WITH FATTY ACID HYDROPEROXIDES

The further conversion of an arachidonic acid hydroperoxide to a leukotriene A (LTA) type epoxide by specific lipoxygenase (LOX) enzymes constitutes a key step in inflammatory mediator biosynthesis. Whereas mammalian 5-LOX transforms its primary product (5S-hydroperoxyeicosatetraenoic acid; 5S-HPETE...

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Main Authors: Zheng, Yuxiang, Brash, Alan R.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
主題:
Enzymology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859502/
https://ncbi.nlm.nih.gov/pubmed/20194505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.084632
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