ROLE OF CHROMATIN ACCESSIBILITY IN THE OCCUPANCY AND TRANSCRIPTION OF THE INSULIN GENE BY THE PANCREATIC TRANSCRIPTION FACTOR PDX-1

Pdx-1 is a hox-like transcription factor that is responsible for the activation of the insulin gene. Prior studies have demonstrated the interaction in vitro of Pdx-1 with short (20-40 nucleotide) DNA fragments corresponding to “A boxes” of the insulin promoter. Precisely how Pdx-1 binds to DNA in t...

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Main Authors: Francis, Joshua, Babu, Daniella A., Deering, Tye G., Chakrabarti, Swarup K., Garmey, James C., Evans-Molina, Carmella, Taylor, David G., Mirmira, Raghavendra G.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617569/
https://ncbi.nlm.nih.gov/pubmed/16901969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2006-0126
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