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ROLE OF CHROMATIN ACCESSIBILITY IN THE OCCUPANCY AND TRANSCRIPTION OF THE INSULIN GENE BY THE PANCREATIC TRANSCRIPTION FACTOR PDX-1
Pdx-1 is a hox-like transcription factor that is responsible for the activation of the insulin gene. Prior studies have demonstrated the interaction in vitro of Pdx-1 with short (20-40 nucleotide) DNA fragments corresponding to “A boxes” of the insulin promoter. Precisely how Pdx-1 binds to DNA in t...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2006
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3617569/ https://ncbi.nlm.nih.gov/pubmed/16901969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2006-0126 |
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