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Glucose Regulation of Insulin Gene Transcription and Pre-mRNA Processing in Human Islets

Glucose is the primary regulator of insulin granule release from pancreatic islets. In rodent islets, the role of glucose in the acute regulation of insulin gene transcription has remained unclear, primarily because the abundance and long half-life of insulin mRNA confounds analysis of transcription...

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Detalhes bibliográficos
Main Authors: Evans-Molina, Carmella, Garmey, James C., Ketchum, Robert, Brayman, Kenneth L., Deng, Shaoping, Mirmira, Raghavendra G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705758/
https://ncbi.nlm.nih.gov/pubmed/17327454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db06-1440
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