Glucose Regulation of Insulin Gene Transcription and Pre-mRNA Processing in Human Islets

Glucose is the primary regulator of insulin granule release from pancreatic islets. In rodent islets, the role of glucose in the acute regulation of insulin gene transcription has remained unclear, primarily because the abundance and long half-life of insulin mRNA confounds analysis of transcription...

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Bibliographic Details
Main Authors: Evans-Molina, Carmella, Garmey, James C., Ketchum, Robert, Brayman, Kenneth L., Deng, Shaoping, Mirmira, Raghavendra G.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705758/
https://ncbi.nlm.nih.gov/pubmed/17327454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db06-1440
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