Liver X Receptor Agonists Augment Human Islet Function through Activation of Anaplerotic Pathways and Glycerolipid/Free Fatty Acid Cycling

Recent studies in rodent models suggest that liver X receptors (LXRs) may play an important role in the maintenance of glucose homeostasis and islet function. To date, however, no studies have comprehensively examined the role of LXRs in human islet biology. Human islets were isolated from non-diabe...

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Hlavní autoři: Ogihara, Takeshi, Chuang, Jen-Chieh, Vestermark, George L., Garmey, James C., Ketchum, Robert J., Huang, Xiaolun, Brayman, Kenneth L., Thorner, Michael O., Repa, Joyce J., Mirmira, Raghavendra G., Evans-Molina, Carmella
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820768/
https://ncbi.nlm.nih.gov/pubmed/20007976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064659
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