Liver X Receptor Agonists Augment Human Islet Function through Activation of Anaplerotic Pathways and Glycerolipid/Free Fatty Acid Cycling

Recent studies in rodent models suggest that liver X receptors (LXRs) may play an important role in the maintenance of glucose homeostasis and islet function. To date, however, no studies have comprehensively examined the role of LXRs in human islet biology. Human islets were isolated from non-diabe...

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Main Authors: Ogihara, Takeshi, Chuang, Jen-Chieh, Vestermark, George L., Garmey, James C., Ketchum, Robert J., Huang, Xiaolun, Brayman, Kenneth L., Thorner, Michael O., Repa, Joyce J., Mirmira, Raghavendra G., Evans-Molina, Carmella
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820768/
https://ncbi.nlm.nih.gov/pubmed/20007976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064659
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