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Proline Facilitates Membrane Insertion of the Antimicrobial Peptide Maculatin 1.1 via Surface Indentation and Subsequent Lipid Disordering

The role of proline in the disruption of membrane bilayer structure upon antimicrobial peptide (AMP) binding was studied. Specifically, (31)P and (2)H solid-state NMR and dual polarization interferometry (DPI) were used to analyze the membrane interactions of three AMPs: maculatin 1.1 and two analog...

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Detalhes bibliográficos
Main Authors: Fernandez, David I., Lee, Tzong-Hsien, Sani, Marc-Antoine, Aguilar, Marie-Isabel, Separovic, Frances
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617439/
https://ncbi.nlm.nih.gov/pubmed/23561526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.01.059
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