Maculatin 1.1 Disrupts Staphylococcus aureus Lipid Membranes via a Pore Mechanism

Maculatin 1.1 (Mac1) showed potent activity against Staphylococcus aureus with an MIC of 7 μM. The mode of action of Mac1 was investigated by combining assays with S. aureus cells and lipid vesicles mimicking their membrane composition. A change in Mac1 conformation was monitored by circular dichroi...

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Bibliografiset tiedot
Päätekijät: Sani, M.-A., Whitwell, T. C., Gehman, J. D., Robins-Browne, R. M., Pantarat, N., Attard, T. J., Reynolds, E. C., O'Brien-Simpson, N. M., Separovic, F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2013
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Mechanisms of Action: Physiological Effects
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719708/
https://ncbi.nlm.nih.gov/pubmed/23689707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00195-13
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