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Common Risk Alleles for Inflammatory Diseases Are Targets of Recent Positive Selection

Genome-wide association studies (GWASs) have identified hundreds of loci harboring genetic variation influencing inflammatory-disease susceptibility in humans. It has been hypothesized that present day inflammatory diseases may have arisen, in part, due to pleiotropic effects of host resistance to p...

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Detalhes bibliográficos
Main Authors: Raj, Towfique, Kuchroo, Manik, Replogle, Joseph M., Raychaudhuri, Soumya, Stranger, Barbara E., De Jager, Philip L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617371/
https://ncbi.nlm.nih.gov/pubmed/23522783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2013.03.001
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