Characterization and Solution Structure of the Factor VIII C2 Domain in a Ternary Complex with Classical and Non-classical Inhibitor Antibodies

The most significant complication for patients with severe cases of congenital or acquired hemophilia A is the development of inhibitor antibodies against coagulation factor VIII (fVIII). The C2 domain of fVIII is a significant antigenic target of anti-fVIII antibodies. Here, we have utilized small...

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Detalhes bibliográficos
Main Authors: Walter, Justin D., Werther, Rachel A., Polozova, Maria S., Pohlman, Julie, Healey, John F., Meeks, Shannon L., Lollar, Pete, Spiegel, P. Clint
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617290/
https://ncbi.nlm.nih.gov/pubmed/23417672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424564
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