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Glutamate Acts as a Partial Inverse Agonist to Metabotropic Glutamate Receptor with a Single Amino Acid Mutation in the Transmembrane Domain

Metabotropic glutamate receptor (mGluR), a prototypical family 3 G protein-coupled receptor (GPCR), has served as a model for studying GPCR dimerization, and growing evidence has revealed that a glutamate-induced dimeric rearrangement promotes activation of the receptor. However, structural informat...

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Bibliografske podrobnosti
Main Authors: Yanagawa, Masataka, Yamashita, Takahiro, Shichida, Yoshinori
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617263/
https://ncbi.nlm.nih.gov/pubmed/23420844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.437780
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