Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7

BACKGROUND AND PURPOSE: The mGlu(7) receptors are strategically located at the site of vesicle fusion where they modulate the release of the main excitatory and inhibitory neurotransmitters. Consequently, they are implicated in the underlying pathophysiology of CNS diseases such as epilepsy and stre...

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Detalhes bibliográficos
Main Authors: Ullmer, C, Zoffmann, S, Bohrmann, B, Matile, H, Lindemann, L, Flor, PJ, Malherbe, P
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514759/
https://ncbi.nlm.nih.gov/pubmed/22747985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02090.x
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