Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

The metabotropic glutamate receptors (mGluRs) form a family of neuromodulatory G-protein-coupled receptors that contain both a seven-helix transmembrane domain (TMD) and a large extracellular ligand-binding domain (LBD) which enables stable dimerization. Although numerous studies have revealed varia...

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Pubblicato in:eLife
Autori principali: Thibado, Jordana K, Tano, Jean-Yves, Lee, Joon, Salas-Estrada, Leslie, Provasi, Davide, Strauss, Alexa, Marcelo Lamim Ribeiro, Joao, Xiang, Guoqing, Broichhagen, Johannes, Filizola, Marta, Lohse, Martin J, Levitz, Joshua
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2021
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102066/
https://ncbi.nlm.nih.gov/pubmed/33880992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67027
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