Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

Chemokine receptors are commonly post-translationally sulfated on tyrosine residues in their N-terminal regions, the initial site of binding to chemokine ligands. We have investigated the effect of tyrosine sulfation of the chemokine receptor CCR2 on its interactions with the chemokine monocyte chem...

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Autores principales: Tan, Joshua H. Y., Ludeman, Justin P., Wedderburn, Jamie, Canals, Meritxell, Hall, Pam, Butler, Stephen J., Taleski, Deni, Christopoulos, Arthur, Hickey, Michael J., Payne, Richard J., Stone, Martin J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617241/
https://ncbi.nlm.nih.gov/pubmed/23408426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.447359
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