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Direct and selective small-molecule activation of proapoptotic BAX
BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as BAX to maintain cell survival. The antiapoptotic BH3-binding groove has been successfully targeted to reactivate apoptosis in ca...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3617124/ https://ncbi.nlm.nih.gov/pubmed/22634637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.995 |
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