Pro-Asthmatic Cytokines Regulate Unliganded and Ligand-Dependent Glucocorticoid Receptor Signaling in Airway Smooth Muscle

To elucidate the regulation of glucocorticoid receptor (GR) signaling under pro-asthmatic conditions, cultured human airway smooth muscle (HASM) cells were treated with proinflammatory cytokines or GR ligands alone and in combination, and then examined for induced changes in ligand-dependent and -in...

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Bibliographic Details
Main Authors: Hu, Aihua, Josephson, Maureen B., Diener, Barry L., Nino, Gustavo, Xu, Shuyun, Paranjape, Chinmay, Orange, Jordan S., Grunstein, Michael M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617099/
https://ncbi.nlm.nih.gov/pubmed/23593222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060452
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