Mechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting β2-adrenoceptor agonist exposure

BACKGROUND: Chronic use of long-acting β(2)-adrenergic receptor (β2AR) agonists (LABAs), resulting in β2AR desensitization, has been associated with increased asthma morbidity. When LABAs are used in combination with inhaled glucocorticoids (GCs), however, asthma control is improved, raising the que...

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Bibliographic Details
Main Authors: Nino, Gustavo, Hu, Aihua., Grunstein, Judith S., Grunstein, Michael M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866838/
https://ncbi.nlm.nih.gov/pubmed/20392484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.02.007
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