IL-13-induced changes in endogenous glucocorticoid metabolism in the lung regulate the proasthmatic response

Endogenous glucocorticoid (GC) activation is regulated by the intracellular GC-activating and -inactivating enzymes 11β-hydroxysteroid dehydrogenase (11β-HSD)1 and 11β-HSD2, respectively, that catalyze interconversion of inert cortisone and its bioactive metabolite cortisol. Because endogenous GCs a...

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Hlavní autoři: Josephson, Maureen B., Jiao, Junfang, Xu, Shuyun, Hu, Aihua, Paranjape, Chinmay, Grunstein, Judith S., Grumbach, Yael, Nino, Gustavo, Kreiger, Portia A., McDonough, Joseph, Grunstein, Michael M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468426/
https://ncbi.nlm.nih.gov/pubmed/22773690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00125.2012
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