Inhibition of gastric tumor growth by a novel HSP90 inhibitor

Heat shock protein 90 (Hsp90) is a molecular chaperone engaging multiple cellular signaling by stabilizing oncoproteins (e.g., Akt and c-Raf) in tumor cells. Whereas Hsp90 inhibitors such as 17-AAG exert promising antitumor effects in clinical trials, current efforts focus on developing agents targe...

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Hlavní autoři: Lu, Chunwan, Liu, Di, Jin, Jing, Deokar, Hemantkumar, Zhang, Yi, Buolamwini, John K., Yu, Xiaoming, Yan, Chunhong, Chen, Xiaoguang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617064/
https://ncbi.nlm.nih.gov/pubmed/23415900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.02.003
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