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Inhibition of gastric tumor growth by a novel HSP90 inhibitor
Heat shock protein 90 (Hsp90) is a molecular chaperone engaging multiple cellular signaling by stabilizing oncoproteins (e.g., Akt and c-Raf) in tumor cells. Whereas Hsp90 inhibitors such as 17-AAG exert promising antitumor effects in clinical trials, current efforts focus on developing agents targe...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3617064/ https://ncbi.nlm.nih.gov/pubmed/23415900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.02.003 |
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