Preclinical and Clinical Evaluation of Intraductally Administered Agents in Early Breast Cancer

Most breast cancers originate in the epithelial cells lining the breast ducts. Intraductal administration of cancer therapeutics would lead to high drug exposure to ductal cells and eliminate preinvasive neoplasms while limiting systemic exposure. We performed preclinical studies in N-methyl-N’-nitr...

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Autori principali: Stearns, Vered, Mori, Tsuyoshi, Jacobs, Lisa K., Khouri, Nagi F., Gabrielson, Edward, Yoshida, Takahiro, Kominsky, Scott L., Huso, David L., Jeter, Stacie, Powers, Penny, Tarpinian, Karineh, Brown, Regina J., Lange, Julie R., Rudek, Michelle A., Zhang, Zhe, Tsangaris, Theodore N., Sukumar, Saraswati
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616888/
https://ncbi.nlm.nih.gov/pubmed/22030751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002368
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