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Use of microarray hybrid capture and next-generation sequencing to identify the anatomy of a transgene

Transgenic animals are extensively used to model human disease. Typically, the transgene copy number is estimated, but the exact integration site and configuration of the foreign DNA remains uncharacterized. When transgenes have been closely examined, some unexpected configurations have been found....

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Dettagli Bibliografici
Autori principali: DuBose, Amanda J., Lichtenstein, Stephen T., Narisu, Narisu, Bonnycastle, Lori L., Swift, Amy J., Chines, Peter S., Collins, Francis S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616733/
https://ncbi.nlm.nih.gov/pubmed/23314155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1463
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