The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA

Hepatitis C Virus (HCV) and other plus-strand RNA viruses typically require the generation of a small number of negative genomes (20–100× lower than the positive genomes) for replication, making the less-abundant antigenome an attractive target for RNA interference(RNAi)-based therapy. Because of th...

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Main Authors: Lisowski, Leszek, Elazar, Menashe, Chu, Kirk, Glenn, Jeffrey S., Kay, Mark A.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2013
主題:
Molecular Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616702/
https://ncbi.nlm.nih.gov/pubmed/23396439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt068
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