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The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA
Hepatitis C Virus (HCV) and other plus-strand RNA viruses typically require the generation of a small number of negative genomes (20–100× lower than the positive genomes) for replication, making the less-abundant antigenome an attractive target for RNA interference(RNAi)-based therapy. Because of th...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616702/ https://ncbi.nlm.nih.gov/pubmed/23396439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt068 |
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