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The risky reliance on small surrogate endpoint studies when planning a large prevention trial

The definitive evaluation of treatment to prevent a chronic disease with low incidence in middle age, such as cancer or cardiovascular disease, requires a trial with a large sample size of perhaps 20,000 or more. To help decide whether to implement a large true endpoint trial, investigators first ty...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Baker, Stuart G., Kramer, Barnett S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616635/
https://ncbi.nlm.nih.gov/pubmed/23565041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1467-985X.2012.01052.x
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