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Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: Effects on striatal dopamine and opioid systems in C57BL/6J mice

Cocaine addiction is a chronic relapsing disease with periods of chronic escalating self-exposure, separated by periods of abstinence/withdrawal of varying duration. Few studies compare such cycles in preclinical models. This study models an “addiction-like cycle” in mice to determine neurochemical/...

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Detalhes bibliográficos
Main Authors: Zhang, Yong, Schlussman, Stefan D., Rabkin, Jacqui, Butelman, Eduardo R., Ho, Ann, Kreek, Mary Jeanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616618/
https://ncbi.nlm.nih.gov/pubmed/23164614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.10.015
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