Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension

Pulmonary hypertension (PH) and cancer pathology share growth factor- and MAPK stress-mediated signaling pathways resulting in endothelial and smooth muscle cell dysfunction and angioproliferative vasculopathy. In this study, we assessed sorafenib, an antineoplastic agent and inhibitor of multiple k...

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Bibliografische gegevens
Hoofdauteurs: Moreno-Vinasco, Liliana, Gomberg-Maitland, Mardi, Maitland, Michael L., Desai, Ankit A., Singleton, Patrick A., Sammani, Saad, Sam, Lee, Liu, Yang, Husain, Aliya N., Lang, Roberto M., Ratain, Mark J., Lussier, Yves A., Garcia, Joe G. N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616402/
https://ncbi.nlm.nih.gov/pubmed/18303084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00169.2007
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