Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension

Pulmonary hypertension (PH) and cancer pathology share growth factor- and MAPK stress-mediated signaling pathways resulting in endothelial and smooth muscle cell dysfunction and angioproliferative vasculopathy. In this study, we assessed sorafenib, an antineoplastic agent and inhibitor of multiple k...

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Bibliografski detalji
Glavni autori: Moreno-Vinasco, Liliana, Gomberg-Maitland, Mardi, Maitland, Michael L., Desai, Ankit A., Singleton, Patrick A., Sammani, Saad, Sam, Lee, Liu, Yang, Husain, Aliya N., Lang, Roberto M., Ratain, Mark J., Lussier, Yves A., Garcia, Joe G. N.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616402/
https://ncbi.nlm.nih.gov/pubmed/18303084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00169.2007
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