Interplay between Homeobox proteins and Polycomb repressive complexes in p16(INK4a) regulation

The INK4/ARF locus regulates senescence and is frequently altered in cancer. In normal cells, the INK4/ARF locus is found silenced by Polycomb repressive complexes (PRCs). Which are the mechanisms responsible for the recruitment of PRCs to INK4/ARF and their other target genes remains unclear. In a...

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Main Authors: Martin, Nadine, Popov, Nikolay, Aguilo, Francesca, O’Loghlen, Ana, Raguz, Selina, Snijders, Ambrosius P, Dharmalingam, Gopuraja, Li, SiDe, Thymiakou, Efstathia, Carroll, Thomas, Zeisig, Bernd B, So, Chi Wai Eric, Peters, Gordon, Episkopou, Vasso, Walsh, Martin J, Gil, Jesús
Formato: Artigo
Idioma:Inglês
Publicado: European Molecular Biology Organization 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616285/
https://ncbi.nlm.nih.gov/pubmed/23455154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.37
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