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Clking on PGC-1α to inhibit gluconeogenesis
The link between Akt activation and gluconeogenic repression remains unclear despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1α, blunting hepatic glucose producti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616263/ https://ncbi.nlm.nih.gov/pubmed/20085730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.12.003 |
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