Evaluation of Lateral Spread of Transgene Expression following Subretinal AAV–Mediated Gene Delivery in Dogs

Dog models with spontaneously occurring mutations in retinal dystrophy genes are an invaluable resource for preclinical development of retinal gene therapy. Adeno-associated virus (AAV) vectors have been most successful; to target the outer retina and RPE they are delivered by subretinal injection,...

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Main Authors: Bruewer, Ashlee R., Mowat, Freya M., Bartoe, Joshua T., Boye, Sanford L., Hauswirth, William W., Petersen-Jones, Simon M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616166/
https://ncbi.nlm.nih.gov/pubmed/23560080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060218
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