SMUG1 BUT NOT UNG DNA GLYCOSYLASE CONTRIBUTES TO THE CELLULAR RESPONSE TO RECOVERY FROM 5-FLUOROURACIL INDUCED REPLICATION STRESS

5-Fluorouracil (5-FU) is a widely utilized cancer chemotherapeutic that causes DNA damage via two mechanisms. Its active metabolite inhibits thymidylate synthase, which deprives cells of TTP and causes the introduction of uracil in DNA. Also, 5-FU is directly incorporated into DNA. Both uracil and 5...

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Detaylı Bibliyografya
Asıl Yazarlar: Nagaria, Pratik, Svilar, David, Brown, Ashley R., Wang, Xiao-hong, Sobol, Robert W., Wyatt, Michael D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616158/
https://ncbi.nlm.nih.gov/pubmed/23253900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2012.12.001
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