SMUG1 BUT NOT UNG DNA GLYCOSYLASE CONTRIBUTES TO THE CELLULAR RESPONSE TO RECOVERY FROM 5-FLUOROURACIL INDUCED REPLICATION STRESS

5-Fluorouracil (5-FU) is a widely utilized cancer chemotherapeutic that causes DNA damage via two mechanisms. Its active metabolite inhibits thymidylate synthase, which deprives cells of TTP and causes the introduction of uracil in DNA. Also, 5-FU is directly incorporated into DNA. Both uracil and 5...

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Hlavní autoři: Nagaria, Pratik, Svilar, David, Brown, Ashley R., Wang, Xiao-hong, Sobol, Robert W., Wyatt, Michael D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616158/
https://ncbi.nlm.nih.gov/pubmed/23253900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2012.12.001
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