Pasireotide is more effective than Octreotide in reducing hepato-renal cystogenesis in rodents with polycystic kidney and liver diseases

In polycystic liver (PLD) and kidney (PKD) diseases, increased cAMP levels trigger hepato-renal cystogenesis. We previously reported that reduction of elevated cAMP by targeting somatostatin receptors (SSTRs) with Octreotide (OCT; a somatostatin analogue that preferentially binds to SSTR2), inhibits...

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Autori principali: Masyuk, Tatyana V, Radtke, Brynn N, Stroope, Angela J, Banales, Jesús M, Gradilone, Sergio A, Huang, Bing, Masyuk, Anatoliy I, Hogan, Marie C, Torres, Vicente E, LaRusso, Nicholas F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616157/
https://ncbi.nlm.nih.gov/pubmed/23172758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26140
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