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Structural and Kinetic Effects of Hypertrophic Cardiomyopathy Related Mutations R146G/Q and R163W on the Regulatory Switching Activity of Rat Cardiac Troponin I
Mutations in cardiac troponin I (cTnI) that cause hypertrophic cardiomyopathy (HCM) have been reported to change the contractility of cardiac myofilaments, but the underlying molecular mechanism remains elusive. In this study, Förster resonance energy transfer (FRET) was used to investigate the spec...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616153/ https://ncbi.nlm.nih.gov/pubmed/23246786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.12.007 |
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