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Structural and Kinetic Effects of Hypertrophic Cardiomyopathy Related Mutations R146G/Q and R163W on the Regulatory Switching Activity of Rat Cardiac Troponin I

Mutations in cardiac troponin I (cTnI) that cause hypertrophic cardiomyopathy (HCM) have been reported to change the contractility of cardiac myofilaments, but the underlying molecular mechanism remains elusive. In this study, Förster resonance energy transfer (FRET) was used to investigate the spec...

詳細記述

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書誌詳細
主要な著者: Zhou, Zhiqun, Rieck, Daniel, Li, King-Lun, Ouyang, Yexin, Dong, Wen-Ji
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616153/
https://ncbi.nlm.nih.gov/pubmed/23246786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.12.007
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