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Targeting 20-HETE producing enzymes in cancer – rationale, pharmacology, and clinical potential

Studies demonstrate that lipid mediator 20-Hydroxyeicosatetraenoic acid (20-HETE) synthesis and signaling are associated with the growth of cancer cells in vitro and in vivo. Stable 20-HETE agonists promote the proliferation of cancer cells, whereas selective inhibitors of the 20-HETE-producing enzy...

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Détails bibliographiques
Auteurs principaux: Alexanian, Anna, Sorokin, Andrey
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615879/
https://ncbi.nlm.nih.gov/pubmed/23569388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S31586
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