Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

The DNA-binding protein TRF2 is essential for telomere protection and chromosome stability in mammals. We show here that TRF2 expression is activated by the Wnt/β-catenin signalling pathway in human cancer and normal cells as well as in mouse intestinal tissues. Furthermore, β-catenin binds to TRF2...

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Detalhes bibliográficos
Main Authors: Diala, Irmina, Wagner, Nicole, Magdinier, Frédérique, Shkreli, Marina, Sirakov, Maria, Bauwens, Serge, Schluth-Bolard, Caroline, Simonet, Thomas, Renault, Valérie M, Ye, Jing, Djerbi, Abdelnnadir, Pineau, Pascal, Choi, Jinkuk, Artandi, Steven, Dejean, Anne, Plateroti, Michelina, Gilson, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615653/
https://ncbi.nlm.nih.gov/pubmed/23429341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.16
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