Laminin alpha 2 enables glioblastoma stem cell growth

OBJECTIVE: Glioblastomas (GBMs) are lethal cancers that display cellular hierarchies parallel to normal brain. At the apex are GBM stem cells (GSCs), which are relatively resistant to conventional therapy. An important driver of malignancy and self-renewal in GSCs are interactions with the adjacent...

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Main Authors: Lathia, Justin D., Li, Meizhang, Hall, Peter E., Gallagher, Joseph, Hale, James S., Wu, Qiulian, Venere, Monica, Levy, Emily, Rani, MR Sandhya, Huang, Ping, Bae, Eunnyung, Selfridge, Julia, Cheng, Lin, Guvenc, Hacer, McLendon, Roger E., Nakano, Ichiro, Sloan, Andrew E., Phillips, Heidi S., Lai, Albert, Gladson, Candece, Bredel, Markus, Bao, Shideng, Hjelmeland, Anita B., Rich, Jeremy N.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615417/
https://ncbi.nlm.nih.gov/pubmed/23280793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23674
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