Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis

BACKGROUND: Reversibility of aberrant methylation via pharmacological means is an attractive target for therapies through epigenetic reprogramming. To establish that pharmacologic reversal of methylation could result in functional inhibition of angiogenesis, we undertook in vitro and in vivo studies...

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Bibliografiske detaljer
Main Authors: Lindner, Daniel J., Wu, Yan, Haney, Rebecca, Jacobs, Barbara S., Fruehauf, John P., Tuthill, Ralph, Borden, Ernest C.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615071/
https://ncbi.nlm.nih.gov/pubmed/23202046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2012.11.010
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