Restoration of DNA-Binding and Growth-Suppressive Activity of Mutant Forms of p53 Via a PCAF-Mediated Acetylation Pathway

Tumor-derived mutant forms of p53 compromise its DNA binding, transcriptional, and growth regulatory activity in a manner that is dependent upon the cell-type and the type of mutation. Given the high frequency of p53 mutations in human tumors, reactivation of the p53 pathway has been widely proposed...

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Main Authors: PEREZ, RICARDO E., KNIGHTS, CHAD D., SAHU, GEETARAM, CATANIA, JASON, KOLUKULA, VAMSI K., STOLER, DANIEL, GRAESSMANN, ADOLF, OGRYZKO, VASILY, PISHVAIAN, MICHAEL, ALBANESE, CHRISTOPHER, AVANTAGGIATI, MARIA LAURA
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3614009/
https://ncbi.nlm.nih.gov/pubmed/20589832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22285
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