Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

The molecular mechanisms that control the balance between antiangiogenic and proangiogenic factors and initiate the angiogenic switch in tumors remain poorly defined. By combining chemical genetics with multimodal imaging, we have identified an autocrine feed-forward loop in tumor cells in which tum...

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Detalhes bibliográficos
Main Authors: Chatterjee, Sampurna, Heukamp, Lukas C., Siobal, Maike, Schöttle, Jakob, Wieczorek, Caroline, Peifer, Martin, Frasca, Davide, Koker, Mirjam, König, Katharina, Meder, Lydia, Rauh, Daniel, Buettner, Reinhard, Wolf, Jürgen, Brekken, Rolf A., Neumaier, Bernd, Christofori, Gerhard, Thomas, Roman K., Ullrich, Roland T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613914/
https://ncbi.nlm.nih.gov/pubmed/23454747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65385
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