Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression

Nutlin-3 selectively activates p53 by inhibiting the interaction of this tumor suppressor with its negative regulator murine double minute 2 (mdm2), while trichostatin A (TSA) is one of the most potent histone deacetylase (HDAC) inhibitors currently available. As both Nutlin-3 and TSA increase the l...

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Autors principals: Sachweh, M C C, Drummond, C J, Higgins, M, Campbell, J, Laín, S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613839/
https://ncbi.nlm.nih.gov/pubmed/23470540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.61
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