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Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression
Nutlin-3 selectively activates p53 by inhibiting the interaction of this tumor suppressor with its negative regulator murine double minute 2 (mdm2), while trichostatin A (TSA) is one of the most potent histone deacetylase (HDAC) inhibitors currently available. As both Nutlin-3 and TSA increase the l...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3613839/ https://ncbi.nlm.nih.gov/pubmed/23470540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.61 |
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