p53-independent p21 induction by MELK inhibition

MELK play critical roles in human carcinogenesis through activation of cell proliferation, inhibition of apoptosis and maintenance of stemness. Therefore, MELK is a promising therapeutic target for a wide range of cancers. Although p21 is a well-known p53-downstream gene, we found that treatment wit...

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Udgivet i:Oncotarget
Main Authors: Matsuda, Tatsuo, Kato, Taigo, Kiyotani, Kazuma, Tarhan, Yunus Emre, Saloura, Vassiliki, Chung, Suyoun, Ueda, Koji, Nakamura, Yusuke, Park, Jae-Hyun
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
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Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601624/
https://ncbi.nlm.nih.gov/pubmed/28938528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18488
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