Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

Recent human trials of treatments for Alzheimer’s disease (AD) have been largely unsuccessful, raising the idea that treatment may need to be started earlier in the disease, well before cognitive symptoms appear. An early marker of AD pathology is therefore needed and it is debated as to whether amy...

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Autori principali: Wright, Amanda L., Zinn, Raphael, Hohensinn, Barbara, Konen, Lyndsey M., Beynon, Sarah B., Tan, Richard P., Clark, Ian A., Abdipranoto, Andrea, Vissel, Bryce
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613362/
https://ncbi.nlm.nih.gov/pubmed/23560052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059586
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