Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)(SL) Mice

BACKGROUND: NADPH oxidase is implicated in neurotoxic microglial activation and the progressive nature of Alzheimer's Disease (AD). Here, we test the ability of two NADPH oxidase inhibitors, apocynin and dextromethorphan (DM), to reduce learning deficits and neuropathology in transgenic mice ov...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Lull, Melinda E., Levesque, Shannon, Surace, Michael J., Block, Michelle L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105011/
https://ncbi.nlm.nih.gov/pubmed/21655287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020153
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares