Catalysis leads to post-translational inactivation of the Type 1 deiodinase and alters its conformation

Previously it was shown that the type 1 deiodinase (D1) is subject to substrate dependent inactivation that is blocked by pretreatment with the inhibitor of D1 catalysis, propylthiouracil (PTU). Using HepG2 cells with endogenous D1 activity we found that while considerable D1-mediated catalysis of r...

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Main Authors: Zhu, Bo, Shrivastava, Ashutosh, Luongo, Cristina, Chen, Ting, Harney, John W., Marsili, Alessandro, Tran, Thuy-Van, Bhadouria, Anulika, Mopala, Radhika, Steen, Amanda I., Larsen, P. Reed, Zavacki, Ann Marie
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612969/
https://ncbi.nlm.nih.gov/pubmed/22544951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-11-0459
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